Thread: Chalk up another one for those who lift weights

Low Creatinine Levels Linked to Diabetes CME
News Author: Anthony J. Brown, MD
CME Author: Désirée Lie, MD, MSEd
Disclosures

Release Date: March 13, 2009; Valid for credit through March 13, 2010 Credits Available

Physicians - maximum of 0.25 AMA PRA Category 1 Credit(s)™ for physicians;
Family Physicians - up to 0.25 AAFP Prescribed credit(s) for physicians

Authors and Disclosures
Anthony J. Brown, MD
Disclosure: Anthony J. Brown, MD, has disclosed no relevant financial relationships.



March 13, 2009 — Lower serum levels of creatinine are associated with increased risk of type 2 diabetes, according to a brief report in the March issue of Diabetes Care.

The authors note that creatinine in serum is a direct indicator of total muscle mass. "Although skeletal muscle is one of the major targets of insulin," write Dr. Tomoshige Hayashi, from Osaka City University Graduate School of Medicine, Japan, and colleagues, "to our knowledge, no prospective study has investigated the association between total skeletal muscle mass and type 2 diabetes."

The current investigation included 8570 men in the Kansai Healthcare Study, an ongoing project examining risk factors for cardiometabolic diseases. The participants were between 40 and 55 years of age and nondiabetic at entry.

Incident diabetes was diagnosed if fasting glucose levels reached 126 mg/dL or higher or if treatment with an oral hypoglycemic agent or insulin was initiated.

After 4 years of follow-up, 877 men were diagnosed with type 2 diabetes. "The multiple-adjusted odds ratio for those who had serum creatinine between 0.40 and 0.60 mg/dL was 1.91 compared with those who had levels between 0.71 and 0.80 mg/dL," the investigators report.

They conjecture that, because resistance training is known to cause muscular hypertrophy, it might be worth exploring whether such training could increase creatinine levels and thereby cut the risk of diabetes.

Diabetes Care. 2009;32:424-426.

Reuters Health Information 2009. © 2009 Reuters Ltd.

Thought this might be of interest to some of you guys.

Nice find adz.. i'd like to read into this further now that you have posted this. I'll do a google search and see what I come up with as i have friend thats borderline diabetic. .. Thanks.

Clinical Context
No study has investigated the association between total skeletal muscle mass and type 2 diabetes, although skeletal muscle is one of the major target organs of insulin. Serum creatinine is a metabolite of creatine, almost all of which is located in skeletal muscle. Because breakdown of creatine is consistent and the amount of creatine per unit of skeletal muscle mass is consistent, plasma creatinine concentration is stable and reflects skeletal muscle mass.

This is a prospective observational study to examine the association between serum creatinine levels and subsequent development of type 2 diabetes in Japanese men.

Study Highlights
The cohort consisted of 11,063 Japanese men aged 40 to 55 years without diabetes at baseline and with serum creatinine levels of less than 2.0 mg/dL.
Participants were all employees of 1 company and were not malnourished.
Diabetes was defined as a plasma fasting glucose level of 126 mg/dL or more or use of an antidiabetic medication or insulin.
Follow-up was conducted annually for 4 years.
2493 men were lost to follow-up and were excluded from final analysis.
Blood samples were drawn after a 12-hour fast for serum creatinine levels.
Questionnaires were administered to ask about physical activity, smoking, alcohol consumption, and other lifestyle factors.
The BMI was calculated based on weight and height.
At baseline and at follow-up, type 2 diabetes was diagnosed if fasting plasma glucose level was 126 mg/dL or higher or if the men took hypoglycemic medication or insulin.
Mean age at baseline was 48 years, mean BMI was 23 kg/m2, mean fasting glucose level was 98 mg/dL, daily alcohol consumption was 27 g of ethanol, 41% to 73% were current smokers, and 12% had a family history of diabetes.
During 4 years of follow-up, type 2 diabetes developed in 877 men.
The lowest category of creatinine levels (0.40 - 0.60 mg/dL) was associated with type 2 diabetes in multiple adjusted models.
After stratification by median BMI, the lowest category of creatinine level was still significantly associated with type 2 diabetes.
The authors concluded that low serum creatinine level was associated with an increased risk for diabetes in Japanese men, independent of BMI.
They suggested that Asian men may have a lower percentage of total skeletal muscle mass than Caucasians at the same BMI level, which puts them at higher risk for diabetes.
They also proposed increased resistance exercise to increase muscle mass, which may reduce the risk for diabetes.
Pearls for Practice
Serum creatinine level is a direct reflection of skeletal muscle mass.
A lower serum creatinine level is associated with an increased risk for the development of type 2 diabetes in Japanese men.

There was more in there that didn't make the cut and paste for some reason.

I would post the link but you need to have a login.